PRINCIPLES OF POPULATION GENETICS EBOOK FREE DOWNLOAD

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Principles of Population Genetics, Third Edition, provides a balanced presentation of theory and . This is THE population genetics textbook, the source text. I have for a number of years taught a course in population genetics for students interested in Digitally watermarked, DRM-free; Included format: PDF; ebooks can be used on all reading devices; Immediate eBook download after purchase. Principles of Population Genetics. Leo P ten Kate, MD, PhD. Em. Prof. of Clinical Genetics. VU University Medical Center. Amsterdam, the Netherlands. Training.

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Molecular population genetics, including coalescent theory, is the subject of Chapter 8. Quantitative genetics is covered in Chapter 9, from the standpoint of genetic variance and covariance components as well as with respect to molecular markers used to detect quantitative trait loci QTLs.

Applications of principles discussed in thetext are illustrated by numerous examples of worked problems, using actual data. Each chapter end, in addition to a complete summary, offers several problems for solution, to reinforce and further develop the concepts.

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To see what your friends thought of this book, please sign up. To ask other readers questions about Principles of Population Genetics , please sign up. See 1 question about Principles of Population Genetics…. Lists with This Book. Community Reviews.

Showing Rating details. Sort order. Sep 15, Sarah rated it liked it Shelves: This is hard to rate, because I don't enjoy textbooks the way I enjoy fiction. However, this book got me through my preliminary examinations to become a PhD candidate. It is one of the best, most thorough, and most understandable genetics textbooks I've read. It's a must for students and other researchers in the field of population genetics. The newer editions even have chapters on population genomics and human genetics.

This is an incredibly useful text! May 15, Amanda rated it really liked it Shelves: A useful reference with clear explanations. It was the recommended textbook for my population genetics class, but I only cracked it open once or twice for that. An easy population genetics companion. Clear, structured and relevant. View 1 comment. Dec 21, Yessenia rated it liked it.

All right. Doesn't stand out much. Supplement 8. What the evolution of the horse really shows: Supplement 9. The human numbers game.

Supplement Some speculations on the origin of human speech. Supplement Il. How do those old men get all the girls? More information on mutations. Selection and city life.

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The impact of the new biology. New York: Oxford University Press This is a comprehensive textbook of human genetics with many examples and pedigrees. It is as up-to-date as any book in this rapidly burgeoning field can ever hope to be. Suggested exercises appear after each chapter. Introduction, mitosis, mitosis in reproduction. Spermatogenesis, oogenesis, the normal chromosome set. Changes in number, Ploidy and Somy, autosomal trisomies, gonosomal abnormalities of number, sexual differentiation, sex chromatin analysis, mosaicism, gonosomalsyndromes of number, the XYY anomaly and behaviour, other disorders of sexual development, chromosomal rearrangement, interchromosomal exchanges, interchromosomal two-break aberrations, multiple-break aberrations, the causes of chromosomal aberrations.

The chromosomal theory, the gene theory, the molecular concept.

Population download free principles genetics of ebook

Dominance, how genes act, pleitrophism. Variable expressivity, incomplete penetrance, age of onset, sex differences in gene expression, causes of variable expressivity, phenocopies, lethal genes. Probability, what the genetic ratios mean, empiric probability, simplifying probability, calculations, significant deviation from expected ratios, special tests for significance, confidence intervals.

X-linkage, terminology, some features of sex-related inheritance, Xlinked conditions, dosage compensation and the Lyon hypothesis, doubtful X-linkage, maternal inheritance. The types of linkage, informative matings for linkage study, modern methods of estimating linkage, known linkage groups, chiasma frequencies, autosomal chromosomai mapping, mapping the X-chromosome.

Methods of ascertainment, correction of truncate complete selection, correction for truncate single selection. Derivation of the random mating law, random mating and multiple loci, genetic inferences from the random mating law, population associations. Terminology, relationship and consanguinity, the general theory of inbreeding, calculating the inbreeding coefficient, uses of the inbreeding coefficient, consanguinity and recessive inheritance, general effect of inbreeding.

Earning a Ph. Prior to joining the Cornell faculty in , he was a professor in the Department of Biology at Pennsylvania State University. Clark's research focuses on the genetic basis of adaptive variation in natural populations, with emphasis on quantitative modeling of phenotypes as networks of interacting genes.

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Human Population Genetics and Genomics - 1st Edition

Principles of Population Genetics , Fourth Edition, is a thoroughly updated introduction to the field that is at last ascending to its rightful position of centrality to evolutionary genomics and human genetics.

Rapid and inexpensive genotyping and sequencing have produced a profusion of data on genetic variation, along with a pressing need to inform students from many fields about the models that describe the underlying processes that give rise to observed patterns of genetic variation.

This book provides a balanced presentation of theory and observation for students at the undergraduate and graduate levels as well as newcomers from fields like human genetics. The logical development of the models of population genetics encourages a deeper understanding of the principles, and the text has been rewritten with the goal to optimize its use as a teaching aid.

It introduces the principles of genetics and statistics that are relevant to population studies, and examines the forces affecting genetic variation from the molecular to the organismic level. Integrated throughout the book are descriptions of molecular methods used to study variation in natural populations, as well as explanations of the relevant estimation theory using actual data. Chapter 1 presents the fundamental observations and means for quantifying amounts and structure of genetic variation in natural populations.

Chapter 2 gives a detailed examination of the implications of random mating for one locus and multiple loci and establishes the basic principles for thinking about mathematical models of variation. Chapter 3 presents the classic Wright-Fisher model as well as the coalescent approaches to random genetic drift.

Chapter 4 adds mutation to models of drift and lays down the foundations for the neutral theory of molecular evolution. Natural selection in its many guises gets a thorough coverage in Chapter 5.

Human Population Genetics and Genomics

Chapter 6 examines population subdivision and its consequences for the distribution of genetic variation among subpopulations, including the hierarchical F statistics used in estimating these effects. Molecular population genetics, including applications of coalescent theory, is the subject of Chapter 7. Evolutionary quantitative genetics is covered in Chapter 8, including an up-to-date treatment of the use of molecular markers for mapping and assisting in selection of quantitative characters.

Chapter 9 is a new addition and covers the exciting field of population genomics, or the analysis of population genetic principles at a genome-wide scale. Finally, because of the explosion in genome-wide polymorphism data in humans and the realization that many problems in empirical population genetics need to be tuned to special, non-equilibrium circumstances of human populations, the authors devote Chapter 10 to human population genetics. Applications of principles discussed in the text are illustrated with numerous examples of worked problems, using actual data.

Many vital Web links are scattered throughout the text to connect the material to up-to-the-minute progress in this exciting field. Each chapter ends with a complete summary and offers several problems for solution, to reinforce and further develop the concepts.

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Population Genetics: A Concise Guide by John H. Customers who bought this item also bought. Page 1 of 1 Start over Page 1 of 1. Molecular Population Genetics. A Primer of Population Genetics.